Tumorimmunology 2019

Tumor Immunogenicity

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Tumor immunogenicity varies greatly between cancers of the same type in different individuals and between different types of cancer. Immunogenicity, which is the ability to induce adaptive immune responses, has been widely analysed by cancer cell transplantation experiments. If rejection requires prior immunization, those transplanted cancer cells (which are known as progressors) are considered intermediate immunogenic. Failure to reject the tumour following immunization against trans-planted cancer cells classifies them as non-immunogenic.